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Initiation of rosiglitazone maleate/metformin hydrochloride in patients with established NYHA Class III or IV heart failure is contraindicated. The following information includes only the average doses of metformin and rosiglitazone. If prior therapy consists of metformin 2,000 mg/day, start with 2 mg/1,000 mg and administer 1 tablet twice daily. Using any of them together with metformin and rosiglitazone may increase your risk of having serious side effects. MANAGEMENT: Close monitoring for the development of hypoglycemia is recommended if ACE inhibitors are coadministered with metformin, particularly in patients with advanced age and/or renal impairment. Use of metformin and rosiglitazone can increase the risk of serious side effects in these patients.

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